Classification of brain edema

Brain edema was first described at autopsy by Reichardt in 1905. With the introduction of electron microscopy it became apparent that edema was present both intracellularly and extracellularly. ,Kiatzo(1994) differentiated vasogenic edema, where fluid accumulates extracellularly in association with a dysfunctional blood-brain barrier, from cytotoxic edema where abnormal intracellular water uptake occurs. More recently, osmotic, hydrostatic, and interstitial edema have been described. Clinically, several of the five potential forms of edema may coexist ( D§§rd§n...§.D.d Mille.L.1991.).

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