Balkaran, B., Char, G., Morris, J.S., Serjeant, B.E., and Serjeant, G.R. (1992). Stroke in a cohort study of patients with homozygous sickle cell disease. Journal of Pediatrics, 120, 360-6.

Koshy, M., Burd, L., Wallace, D., Moawad, A., and Baron, J. (1988). Prophylactic red-cell transfusions in pregnant patients with sickle cell disease. A randomized cooperative study. New England Journal of Medicine, 319, 1447-52.

Platt, O.S., et al. (1991). Pain in sickle cell disease. Rates and risk factors. New England Journal of Medicine, 325, 11-16. Serjeant, G.R., et al. (1981) Outbreak of aplastic crises in sickle cell anaemia associated with parvovirus-like agent. Lancet, ii, 595-7.

Serjeant, G.R., De Ceulaer, C., Lethbridge, R., Morris, J.S., Singhal, A., and Thomas, P.W. (1994). The painful crisis of homozygous sickle cell disease—clinical features. British Journal of Haematology, 87, 586-91.

10.6.2 Prevention and management of complications

G. R. Serjeant and M. Singer

General. principles

Aplastic ..crisis

Clinical: . . features Management

Acute splenicseguestration Clinical, . .features


Septicemia Clinicaljeatures


Preventioncf .pneMmococcaLi.nfecti.on Stroke

Clinical. . features Management Painfuicrisis Clinicalfeatures Management Other..treatments Natural . . historv Acute chest.síndrome Clinicalfeatures

Management Pregnancy Management

Postoperative.. management Bii.b!ioigraiphv

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