Bupropion is a relatively selective dopamine-uptake blocker that is effective in treating depression ( Table 1). Its efficacy and side-effect profile are similar to those of the selective serotonin reuptake inhibitors, but bupropion does not cause sexual dysfunction. High doses are associated with an increased risk of seizures.
Trazodone and nefazodone, which are chemically related compounds with an affinity for several receptors and uptake transporters, also treat depression ( TableJ). Although trazodone lacks anticholinergic side-effects, it is highly sedative.
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