Antistreplase (anisoylated plasminogen streptokinase activator complex (APSAC)) has greater fibrin specificity than streptokinase and relies on the fibrin-binding action of the lys-plasminogen site to localize the complex specifically to the clot. Local tissue enzymes split off the acyl group of APSAC which shields the plasminogen catalytic site, allowing the streptokinase-plasminogen complex to convert plasminogen to plasmin in a more fibrin-specific manner. Antistreplase therapy has the advantage of ease of administration, as it is given as a single intravenous injection. Antistreplase has not been directly compared with alteplase or streptokinase with regard to mortality in large clinical trials, but it is probably equivalent to alteplase in most respects.

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