Antibiotic

Ethambutol Streptomycin Amphotericin B

Fluconazole Itraconazole Flucytosine

Acyclovir

Ganciclovir

Meningitis and fasciitis: 2.4 g, 4-6h, IV Endocarditis: 1.2 g, 4 h, IV Pneumonia: 0.6-1.2 g, 6 h, IV

1 g, 12 h, maintain trough 5-10 mg/l Colitis 125 mg, 6 h, oral

400 mg, 12 h * 3, then daily; can double Keep trough > 20 mg/l in staphylococcal endocarditis

1-1.5 mg/kg, 8 h, but maintain trough < 2 mg/l, peak 5-10 mg/l or use nomogram for once daily dosing (7 mg/kg)

20 mg, 12 h, IV except pseudomonal pneumonia 400 mg, 8 h, IV/oral

Pneumocystis 120 mg/kg, 14 days

50 mg/kg/day, IV/oral

0.5 h, 8 h, IV; 1 g, 8 h, as required 450-600 mg, 24 h, 6 months oral/IV 300 mg, 24 h, 6 months oral/IV 1.5-2 g, 24 h, 2 months oral

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