Alphablockers

Some a-receptor blockers are non-selective, such as phentolamine (a 1- and a2-blockade), and some are selective, such as labetalol (a1- and b-blocker). Stimulation of the a1 receptor causes arteriolar and venous constriction, and stimulation of the a 2 receptor causes decreased central sympathetic outflow. This type of drug is particularly useful in the treatment of pheochromocytoma crises, hypertension following intracranial hypertension, and pregnancy-induced hypertension ( Tietjen et al.

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