Anaphylactic and anaphylactoid reactions, ranging in severity from mild dyspnea to bronchospasm, from periorbital swelling to angio-edema, and rarely shock, may sometimes be seen with streptokinase. Urticaria, itching, flushing, nausea, headache, and musculoskeletal pain have also been observed, as have delayed reactions such as vasculitis and interstitial nephritis. Most reactions can be managed with antihistamines and/or corticosteroids, but severe reactions mandate immediate cessation of therapy and treatment with adrenergic agents, antihistamine, and/or corticosteroid. Minor allergic reactions may occur to a lesser extent with the other fibrinolytic agents.
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