1. Alloimmunization: granulocytes provide a powerful antigenic stimulus resulting in the formation of HLA- and granulocyte-specific antibodies which cause platelet refractoriness and febrile transfusion reactions.
2. Transmission of infection, particularly cytomegalovirus and toxoplasmosis.
3. Severe pulmonary infiltration with pulmonary edema, white cell sequestration, and exacerbation of pre-existing pulmonary infection. This is particularly severe if the patient is being treated concurrently with amphotericin B.
4. Graft versus host disease is a rare possibility.
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