Adverse effects

Adverse effects are few and usually mild enough to allow home treatment for patients on regular IVIg.

1. Immune-mediated reactions with vasomotor disturbance and muscle pains. Anaphylaxis is very rare, but can occur in IgA-deficient patients who have IgA antibodies.

2. Hemolysis occurs rarely owing to the presence of blood group antibodies in IVIg.

3. Virus transmission: this is a small but real risk, particularly in IVIg preparations that have not undergone an inactivation step, and there have been outbreaks of hepatitis viruses in the recent past.

4. Renal function can be further compromised in patients with pre-existing renal impairment.

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