Adverse effects

1. Allergic reactions: urticaria occurs in 1 to 3 per cent; anaphylaxis is very rare, particularly if flow rates are kept below 30 ml/min.

2. Transmission of infection.

3. Hemolysis if ABO-incompatible fresh frozen plasma is transfused and potent anti-A or anti-B causes lysis of red cells.

4. Fluid overload.

5. Transfusion-related lung injury (very rare). This results from potent antigranulocyte antibodies in donor plasma which cause leukocyte aggregation in pulmonary vessels and acute lung injury.

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