Acidifying agents

Treatment of metabolic alkalosis with chloride-containing acids has been suggested, but most of these substances have been associated with deleterious side-effects. Lysine chloride and arginine chloride can cause hyperglycemia and hyperkalemia, and worsen pre-existing renal failure. Ammonium chloride can result in cardiac, respiratory, and neurological complications, particularly in cases of rapid administration and in patients with renal or hepatic failure. Thus these substances are best avoided in the treatment of metabolic alkalosis.

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