Info

Plexin-A

Plexin-D1

'immunoglobulin-like domain

§ MET-related sequence

0 CUB domain

U G-P repeats

MAM domain

U C1 domain

SEMA domain

0 C2 domain

1

ra Basic domain

Fig. 1. Secreted semaphorins and their receptors. Most class 3 semaphorins bind to neuropilins and use plexin-As as signaling subunits. Cell adhesion molecules are also part of the receptor complex for class 3 semaphorins. SEMA3E directly signals through plexin-Dl. Neuropilin-1 can also bind VEGF.

Fig. 1. Secreted semaphorins and their receptors. Most class 3 semaphorins bind to neuropilins and use plexin-As as signaling subunits. Cell adhesion molecules are also part of the receptor complex for class 3 semaphorins. SEMA3E directly signals through plexin-Dl. Neuropilin-1 can also bind VEGF.

chemotropic axon guidance molecules are involved in many pathological processes such as cancers [3]. I will review here recent studies on the function in cancer of diffusible axon guidance molecules from three major families of the netrins, the slits and the semaphorins.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment