Attwell, D. and Laughlin, S.B., 2001, An energy budget for signaling in the grey matter of the brain. J. Cerebral
Blood Flow and Metabol. 21: 1133-1145 Bacich, D.J., Ramadan, E., O'Keefe, D.S., Bukhari, N., Wegorzewska, I., Ojeifo, O., Olszewski, R., Wrenn, C.C., Bzdega, T., Wroblewska, B., Heston, W.D.W. and Neale, J.H., 2002, Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. J. Neurochem. 83: 20-29 Baslow, M.H., 1997, A review of phylogenetic and metabolic relationships between the N-acylamino acids, N-acetyl-L-aspartic acid and N-acetyl-L-histidine in the vertebrate nervous system. J. Neurochem. 68 (4): 1335-1344.
Baslow, M.H., 2000, Functions of N-acetyl-L-aspartate and N-acetyl-L-aspartylglutamate in the vertebrate brain. Role in glial cell-specific signaling. J. Neurochem. 75: 453-459 Baslow, M.H., 2002, Evidence supporting a role for N-acetyl-L-aspartate as a molecular water pump in myelinated neurons in the central nervous system. An analytical review. Neurochem. Int. 40 (4): 295-300 Baslow, M.H., 2003a, Brain N-acetylaspartate as a molecular water pump and its role in the etiology of
Canavan disease: A mechanistic explanation. J. Mol. Neurosci. 21: 185-189 Baslow, M.H., 2003b, N-acetylaspartate in the vertebrate brain: Metabolism and function. Neurochemical Res. 28 (6): 941-953
Baslow, M.H., 2004, N-acetylaspartate and N-acetylaspartylglutamate. In: Handbook of Neurochemistry and Molecular Neurobiology, 3 rd Ed., Abel Lajtha, Editor-in-Chief. Vol. 6, Chapter 17, Kluwer Academic/Plenum Publishers, New York, N.Y., USA (in process) Baslow, M.H. and Guilfoyle,D.N., 2002, Effect of N-acetylaspartic acid on the diffusion coefficient of water: A proton magnetic resonance phantom method for measurement of osmolyte-obligated water. Analyt. Biochem. 311 (2): 133-138
Baslow, M.H., Suckow, R. F., Gaynor, K., Bhakoo, K.K., Marks, N., Saito, M., Saito, Mitsuo, Duff, K., Matsuoka, Y. and Berg, M.J., 2003, Brain damage results in downregulation of N-acetylaspartate as a neuronal osmolyte. NeuroMol. Med. 3 (2): 95-103 Baslow, M.H., Dyakin, V.V., Nowak, K., Hungund, B. and Guilfoyle, D.N., 2005, 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice. Evidence of a link between neuron NAAG release and hyperemia. J. Mol. Neurosci. 26, (3); 1-16 Berry II, M.J. and Meister, M., 1998, Refractoriness and neural precision. J. Neurosci. 18: 2200-2211 Birken, D.L. and Oldendorf, W.H., 1989, N-acetyl-L-aspartic acid: a literature review of a compound prominent in H-NMR spectroscopic studies of brain. Neurosci. Biobehav. Rev. 13: 23-31 Boltshauser, E., Schmitt, B., Wevers, R.A., Engelke, U., Burlina, A.B. and Burlina, A.P., 2004, Follow-up of a child with hypoacetylaspartia. Neuropediatrics 35: 255-258 Bzdega, T., Crowe, S.L., Ramadan, E.R., Sciarretta, K.H., Olszewski, R.T., Ojeifo, O.A., Rafalski, V.A.. , Wroblewska, B. and Neale, J.H., 2004, The cloning and characterization of a second brain enzyme with NAAG peptidase activity. J. Neurochem. 89: 627-635 Chacron, M.J., Longtin, A. and Maler, L., 2001, Negative interspike interval correlations increase the neuronal capacity for encoding time-dependent stimuli. J. Neurosci. 21: 5328-5343 Choi, I-Y. and Gruetter, R., 2001, In vivo 13 C NMR measurement of total brain glycogen concentrations in the conscious rat. Proc. Intl. Soc. Mag. Reson. Med. 9: 210 Clifford, C.W. and Ibbotson, M.R., 2000, Response variability and information transfer in directional neurons of the mammalian horizontal optokinetic system. Visual Neurosci. 17: 207-215 Coyle, J.T., 1997, The nagging question of the function of N-acetylaspartylglutamate. Neurobiol. of Dis. 4:231238
Henry, P.-G., Tkac, I. And Gruetter, R., 2003, 'H-localized broadband 13 C NMR spectroscopy of the rat brain in vivo at 9.4 T. Mag. Reson. Med. 50: 684-692 Hyder, F., Rothman, D.L. and Shulman, R.G., 2002, Total neuroenergetics support localized brain activity:
implications for the interpretation of fMRI. Proc. Nat. Acad. Sci. 99:10771-10776 Karelson, G., Ziegler, A., Kunnecke, B. and Seelig, J., 2003, Feeding versus infusion: a novel approach to study the NAA metabolism in rat brain. NMR in Biomed. 16: 413- 423 Klugmann, M., Symes, C.W., Klaussner, B.K., Leichtlein, C.B., Serikawa, T., Young, D. and During, M.J., 2003, Identification and distribution of aspartoacylase in the postnatal rat brain. Neuroreport 14:18371840
Kozikowski, A.P., Zhang, K., Nan, F., Petukov, P.A., Grajkowska, E., Wroblewski, J.T., Yamamoto, T., Bzdega, T., Wroblewska, B., and Neale, J.H., 2004, Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J. Medicinal Chem. 47: 1729-1738 Logothetis, N.K., 2003, The underpinnings of the BOLD functional magnetic resonance imaging signal. J. Neurosci. 23: 3963-3971
Lu, Z.H., Chakraborty, G., Ledeen, R.W., Yahya, D. and Wu, G., 2004, N-acetylaspartate synthase is bimodally expressed in microsomes and mitochondria in brain. Brain Res. Mol. Brain Res. 122: 71-78 Mackel, R. and Brink, E., 2003, Conduction of neural impulses in diabetic neuropathy. Clin. Neurophysiol. 114:248-255
Madhavarao, C.N., Chinopoulos, C., Chandrasekaran, K. and Namboodiri, M.A.A., 2003, Characterization of the N-acetylasparate biosynthetic enzyme from rat brain. J. Neurochem. 86: 824-835 Madhavarao, C.N., Moffett, J.R., Moore, R.A., Viola, R.E., Namboodiri, M.A. and Jacobowitz, D.M., 2004, Immunohistochemical localization of aspartoacylase in the rat central nervous system. J. Comp. Neurol. 472: 318-329
Moreno, A., Ross, B.D. and Bluml, S., 2001, Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by 13 C MRS and [1-13 C] glucose infusion. J. Neurochem. 77: 347-350 Neale, J.H., Bzdega, T. and Wroblewska, B., 2000, N-acetylaspartylglutamate: The most abundant peptide neurotransmitter in the mammalian central nervous system. J. Neurochem. 75: 443-452 Raichle, M. E. and Gusnard, D. A. 2002, Appraising the brain's energy budget, Proc. Natl. Acad. Sci. USA, 99: 10237-10239.
Robinson, M.B., Blakely, R.D., Couto, R. and Coyle, J.T., 1987, Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. J. Biol. Chem. 262: 14498-14506 Saadoun, S., Papadopoulos, M.C., Davies, D.C., Krishna, S. and Bell, B.A., 2002, Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol. Neurosurg. Psychiatry 72: 262-265 Schoepp, D.D., Jane, D.E. and Monn, J.A., 1999, Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacol. 38: 1431-1476 Smith, A.J., Blumenfeld, H., Behar, K.L., Rothman, D.L., Shulman, R.G. and Hyder, F., 2002, Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI. Proc. Natl. Acad. Sci. 99: 1076510770
Thomas, D.L., Lythgoe, Pell, G.S., Calamante, F. and Ordidge, R.J., 2000, The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging. Phys. Med. Biol. 45: R97-R138 Tsacopoulos, M., 2002, Metabolic signaling between neurons and glial cells: a short review. J. Physiol. 96: 283288
Tyson, R.L. and Sutherland, G. R., 1998, Labeling of N-acetylaspartate and N-acetylaspartylglutamate in ratneocortex, hippocampus and cerebellum from [1-13 C] glucose. Neurosci. Lett. 251: 181-184 Vanzetta, I., and Grinvald, A., 1999, Increased cortical oxidative metabolism due to sensory stimulation:
implications for functional brain imaging. Science 286: 1555-1558 Zarahn, E., 2001, Spatial localization and resolution of BOLD fMRI. Curr. Opin. In Neurobiol. 11: 209-212 Zonta, M., Angulo, M.C., Gobbo, S., Rosengarten, B., Hossmann, K-A., Pozzan, T. and Carmignoto, G., 2003, Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature Neurosci. 6 (1): 43-50
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