Aspa

activity, 150 antibodies, 149 cDNA expression, 167 gene expression, 150 gene maps, 165 gene transfer to CD mouse, 84 mutations, 166 ASPA knockout mouse lipid synthesis study, 150

ASPA-mediated catalysis, 154 ASPAnull knockout (KO) mouse, 132 ASPA-positive cells, 149 Aspartate aminotransferase activity of, 59 pathway of, 59 Aspartate aminotransferase pathway, 154 Aspartoacylase assay, 31-32, 34 calculation of specific activity, 32 protein determination, 32 statistical analysis, 32 Aspartoacylase deficiency, 78 Aspartoacylase enzyme in mammalian brain, 28 oligodendrocytes, 14 Aspartoacylase II, 67 Aspartoacylase activity in cellular, 35 Aspartoacylase expression in corpus callosum, 14

Aspartoacylase gene, 78

Asp-NAT see L-Aspartate N-acetyltransferase

Asp-NAT

complex stability of, 56 Astrocyte mGluR3 receptor, 107 Astrocytes in brain, 3

Astrocytic processes neuron-associated, 102

Atrophy of brain, 213

Atrophy of brainstem, 258

Assay of NAA-Synthase in Pig Retina, 133

Autoimmune encephalomyelitis, 206

Avidin-biotin complex method, 8

Avidinbiotin-peroxidase, 2

Axonal amyloid precursor protein, 205 NAA levels of , 212 neurofilament phosphorylation of, 212 pathology of, 204 Axon-free nerves, 38 Axon-to-glia signaling agent, 310 Axoplasm dialysis of, 308

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