Tight Junctions And Metastasis Of Breast Cancer

Tracey A. Martin

Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK

Abstract: TJs are the apical most structure between epithelial and endothelial cells.

Although well known as functioning as a control for paracellular diffusion of ions and certain molecules, it has recently become apparent that the TJ has a vital role in maintaining cell integrity and that loss of cohesion of the TJ structure can lead to invasion and thus metastasis of breast cancer cells.

Keywords: TJ, metastasis, breast cancer, occludin

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