The Role Of The Hgf Regulatory Factors In Breast Cancer

Chemo Secrets From a Breast Cancer Survivor

Breast Cancer Survivors

Get Instant Access

Christian Parr and Wen G Jiang

Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University,

Heath Park, Cardiff, CF14 4XN, UK

Abstract: Hepatocyte growth factor (HGF) plays a pivotal role in the invasion and motility of breast cancer cells, and is also a key angiogenic and lym-phangiogenic factor. The cytokine, which is primarily synthesised as inactive pro-HGF by stromal fibroblasts in breast tumours, requires activation to function as a biologically active factor. A number of pro-HGF activators have been identified in recent years, together with some naturally occurring activation inhibitors. This chapter discusses the impact of the HGF activators and activation inhibitors in the development and metastasis of breast cancer, and discusses their potential therapeutic value.

Keywords: breast cancer, hepatocyte growth factor, HGF activator (HGFA), HAI-1, HAI-2, matriptase, c-MET

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment