The Role Of The Hgf Regulatory Factors In Breast Cancer

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Christian Parr and Wen G Jiang

Metastasis and Angiogenesis Research Group, School of Medicine, Cardiff University,

Heath Park, Cardiff, CF14 4XN, UK

Abstract: Hepatocyte growth factor (HGF) plays a pivotal role in the invasion and motility of breast cancer cells, and is also a key angiogenic and lym-phangiogenic factor. The cytokine, which is primarily synthesised as inactive pro-HGF by stromal fibroblasts in breast tumours, requires activation to function as a biologically active factor. A number of pro-HGF activators have been identified in recent years, together with some naturally occurring activation inhibitors. This chapter discusses the impact of the HGF activators and activation inhibitors in the development and metastasis of breast cancer, and discusses their potential therapeutic value.

Keywords: breast cancer, hepatocyte growth factor, HGF activator (HGFA), HAI-1, HAI-2, matriptase, c-MET

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