The Genetic Control Of Breast Cancer Metastasis

Rajeev S. Samant, Oystein Fodstad, and Lalita A. Shevde

Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36688, USA

Abstract: Metastasis of breast cancer is a complex event involving coordinated cross-talk of several proteins. Genes that control the resultant metastasis can be broadly classified as metastasis promoter genes (MPGs) and metastasis suppressor genes (MSGs). There is an explosion of information in the studies that focus on these genes; however, thus far, a very few of them are actually tested clinically and/or in vivo functionally. In this chapter we will focus on the metastasis controlling genes that have been tested for clinical relevance or functional properties in breast cancer metastasis models.

Keywords: metastasis suppressing genes (MSGs), functional validation, gene discovery

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