Table Of Contents

List of Contributors ix

Chapter 1 1

Metastasis of breast cancer: an introduction

Robert E. Mansel, Oystein Fodstad, and Wen G. Jiang

Chapter 2 7

The genetic control of breast cancer metastasis

Rajeev S. Samant, Oystein Fodstad, and Lalita A. Shevde

Chapter 3 31

BRCA1 in initiation, invasion, and metastasis of breast cancer: a perspective from the tumor microenvironment

Shaun D. McCullough, Yanfen Hu, and Rong Li

Chapter 4 47

Cell motility and breast cancer metastasis

Marc E. Bracke, Daan De Maeseneer, Veerle Van Marck, Lara Derycke, Barbara Vanhoecke, Olivier De Wever, and Herman T. Depypere

Chapter 5 77

Tight junctions and metastasis of breast cancer

Tracey A. Martin

Chapter 6 111

Cell adhesion molecules in breast cancer invasion and metastasis

Lalita A. Shevde and Judy A. King

Chapter 7 137

Endocrine resistance and breast cancer invasion

Stephen Hiscox, Julia Gee, and Robert I. Nicholson

Chapter 8 151

The role of aromatase and other oestrogen producing enzymes in mammary carcinogenesis

Mohamed Salhab and Kefah Mokbel

Chapter 9 171

The role of the HGF regulatory factors in breast cancer

Christian Parr and Wen G. Jiang

Chapter 10 203

The insulin-like growth factor-1 ligand in breast cancer management

Yoon M. Chong, Ash Subramanian, and Kefah Mokbel

Chapter 11 219

Lymphangiogenesis and metastatic spread of breast cancer

Mahir A. Al-Rawi and Wen G Jiang

Chapter 12 241

Breast cancer secreted factors alter the bone microenvironment

Valerie A. Siclari, Theresa A. Guise, and John M. Chirgwin

Chapter 13 259

Cyclooxygenease-2 and breast cancer

Gurpreet Singh-Ranger and Kefah Mokbel

Chapter 14 279

Prognostic and predictive factors in human breast cancer

Soe Maunglay, Douglas C. Marchion, and Pamela N. Münster

Chapter 15 307

Molecular imaging in metastatic breast cancer

C.P. Schroder, GAP. Hospers, P.H.B. Willemse, P.J. Perik, E.F.J. de Vries, P.L. Jager, W.T.A. van der Graaf, M.N. Lub-de Hooge, and E.G.E. de Vries

Chapter 16 321

Detection of disseminated tumor cells in the bone marrow and blood of breast cancer patients

Volkmar Müller and Klaus Pantel

Chapter 17 333

Sentinel lymph node biopsy in early-stage breast cancer

Amit Goyal and Robert E. Mansel

Chapter 18 355

Surgical management of patients with metastatic breast cancer

Adam I. Riker, SuHu Liu, Mona Hagmaier, Matthew J. D. D'lessio, and Charles E. Cox

Chapter 19 373

Therapeutic aspect of metastatic breast cancer: chemotherapy

Robert C.F. Leonard and Thinn P. Pwint

Chapter 20 389

The diagnosis and treatment of bone metastases in breast cancer

Allan Lipton

Chapter 21 405

Hormonal therapies of metastatic breast cancer: the past and the present

Jürgen Geisler and Per Eystein Lonning

Index 425

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