Selectins

The selectins are a group of cell surface lectins that mediate the adhesion between leukocytes, platelets, and endothelial cells under blood flow (116, 117). Selectin mediated adhesion ensures that leukocytes roll in the direction of flow, which is a prerequisite for recruitment of leukocytes to areas of injury and inflammation. The selectin family is small, consisting of three closely related proteins - L-selectin, E-selectin, and P-selectin—expressed by both platelets and vascular endothelium.

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