While P-cadherin (placental cadherin) is expressed in the myo-epithelium in the normal, nonlactating mammary gland, many ductal (but not lobular) carcinomas, express P-cadherin, even though they are thought to be of epithelial origin. In ductal carcinoma in situ as well, a high grade is associated with increased P-cadherin expression. P-cadherin expression correlates with increased tumor aggressiveness, high proliferation rate, and histologic grade, absence of ER/PR, high c-ErbB-2, and poor prognosis (65). The causal role of P-cadherin in aggressive tumor cell behavior is yet to be determined since transgenic mice overexpressing P-cadherin do not develop spontaneous mammary tumors (66).

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Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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