Pcadherin

While P-cadherin (placental cadherin) is expressed in the myo-epithelium in the normal, nonlactating mammary gland, many ductal (but not lobular) carcinomas, express P-cadherin, even though they are thought to be of epithelial origin. In ductal carcinoma in situ as well, a high grade is associated with increased P-cadherin expression. P-cadherin expression correlates with increased tumor aggressiveness, high proliferation rate, and histologic grade, absence of ER/PR, high c-ErbB-2, and poor prognosis (65). The causal role of P-cadherin in aggressive tumor cell behavior is yet to be determined since transgenic mice overexpressing P-cadherin do not develop spontaneous mammary tumors (66).

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