Pamidronate

In a randomized, placebo-controlled trial in women with stage IV breast cancer and osteolytic metastases (N = 751), women receiving pamidro-nate (90 mg via 2-hour infusion) every 3 to 4 weeks had a significant reduction in SREs compared with placebo (53% versus 68%, P < 0.001), and pamidronate extended the median time to first SRE by 5.7 months compared with placebo (P < 0.001) (6). Pamidronate also provided significant long-term palliation of bone pain compared with significantly increased mean pain scores in the placebo group (P = 0.015), and analgesic use in the pamidronate group was signifycantly lower than in the placebo group (P < 0.001).

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