Nm231618

Noggin 244, 248

NSAIDs 259, 261, 262,

270, 271 Nuclear factor-kappaB ligand , see also RANKL 17, 267, 400

Obstructive jaundice 363

Oestrone 153, 159

Oncotype DX 291, 292

Oophorectomy 38, 295, 405,

OPG 244, 248, 249

OPN, see Osteopontin ORR, overall response rates 379, 383, 384

Osteoclast 242-251, 393, 400

Osteonectin, also

Osteopontin

245, 247 Ovarian suppression 5, 407, 408 Oxygen-derived free radicals 244

p450 155, 156

Paclitaxel 376-385

PAI-1, plasminogen activator inhibitor type 53, 290

Pamidronate 375, 389, 391,

394-399, 401 PAR2, protease-activated receptor

Paracellin, see claudins 85, 93 P-cadherin, placental cadherin 54, 57, 58, 60-62,

115,116

PD158780, EGFR inhibitor 141

PDGF 244, 247, 269

PDZ motifs, see ZOs 79

PECAM, platelet endothelial cell adhesion molecule 120, 121 PET, positron emission tomography 4, 281,

307-316, 392

PGE synthase 261

PGE2, prostaglandin E2 37,

PGG2, prostaglandin G2 260

PGH2, prostaglandin H2 269

Phagocytosis 51

Phospholipase C-y 174

Phospholipase C, gamma 140

Phospholipase D 140

PI3-K pathway 225, 226

Plakoglobin 55, 114

Plasminogen 10, 172

plasminogen activator inhibitor type 1, PAI-1 53, 290

plasminogen activators ...10, 52, 177, 179, 182, 185, 290

Podoplanin 219, 221, 226

Ponsin 80, 93

Positive surgical margins, after breast surgery 356

POX, peroxidase 262, 322

PR, progesterone receptor 60, 61, 92, 115,

208, 209, 263-265, 279, 287, 288, 290, 295, 307, 309, 314-316, 384 Predictive factors 3, 279, 280, 285, 287, 289, 296, 321, 346

Progestagen 161

Prognostic factors ...10, 20, 175, 208, 230, 244, 248, 279-281, 285-287, 290, 321, 325, 356, 360, 361, 364 Promegestone 161

Prostaglandin synthetase 260,

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