Ncadherin

Normal epithelial cells express E-cadherin. However, tumor cells that have undergone an EMT begin to inappropriately express N-cadherin (neural cadherin). Expression of N-cadherin in mammary tumor cell lines leads to increased cell migration and invasion, regardless of E-cadherin expression (56, 57, 62). It has also been suggested that N-cadherin promotes breast cancer metastasis by reestablishing homophilic cell-cell adhesion in metastasis (57). In highly invasive breast tumors, N-cadherin was shown to replace E-cadherin at cell-cell contacts, and it has been proposed that N-cadherin mediates carcinoma cell interaction with mammary stromal and endothelial cells. Moreover, intravenous injection of MCF7 cells engineered to overexpress N-cadherin into nude mice results in increased metastasis, compared to parent MCF7 cells lacking N-cadherin. N-cadherin expression influences downstream signaling from the FGFR. Suyama et al., 2002, have implicated a direct interaction between N-cadherin and FGFR, resulting in receptor stabilization and prolonged signaling by FGF (59). N-cadherin-expressing breast carcinoma cells were specifically sensitized to FGF-2-induced invasion and upregulation of the proteolytic enzyme MMP-9. However, the findings are consistent with the observation that, although breast carcinoma cells expressing N-cadherin are more motile and invasive (57, 58) and many human breast cancers express N-cadherin, its presence does not correlate with poor survival (12, 63, 64). It is possible that additional events besides N-cadherin misexpression, such as overexpression of FGF or its receptor, decrease in E-cadherin expression, or increased levels of metal-loproteinases, are required to act in concert with N-cadherin to promote mammary tumor cell invasion and metastasis in vivo (11).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment