Lselectin

While there are no studies that report a role for L-selectin in the metastasis of breast cancer, in colon cancer, L-selectin serves as a molecular link between recruitment of inflammatory leukocytes to the sites of tumor cell emboli in microvasculature and their potential to facilitate metastasis (131). Cancer metastasis is also known to be impaired in L-selectin-deficient mice (132). In melanoma, L-selectin and ICAM-1 contribute cooperatively to the antitumor reaction by regulating lymphocyte infiltration to the tumor (133, 134). In another melanoma model of cancer L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs (135).

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