R.E. Mansel et al. (eds.), Metastasis of Breast Cancer, 171-202. © 2007 Springer.

early development of tumours. Beyond the classical cell-matrix interactions (as already discussed in chapter 4), cytokines and growth factors produced by stromal cells are vital to the development of metastasis. Stromal cells, mainly fibroblasts in mammary tumours, produce a rich array of cytokines. One of the most documented stromal-derived factors is a cytokine known as hepatocyte growth factor (HGF). HGF plays a plethora of roles in tumour growth and metastasis. This cytokine demonstrates the ability to stimulate proliferation, dissociation, migration, and invasion in a wide variety of tumour cells, and is also a potent angio-genic and lymphangiogenic factor. The investigation of HGF, and the factors that govern the influence of HGF, may therefore lead to exciting new strategies to combat the metastatic spread of tumours.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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