card=cardiotoxicity CMF=cyclophosphamide/methotrexate/5-fluorouracil

FEC/FAC/AC/EC=doxorubicine or epirubicin with CF HFS=hand-foot syndrome m=myelotoxicity mu=mucocitis n=nausea nephro=nephrotoxicity neu=neurotoxicity Tratz=Trastuzumab v=vomiting

Table 3. Chemotherapy trials showing survival benefit in metastatic breast cancer

First Author

No. of Patients


OS (months)


O'Shaughnessy J

511 (2nd-line)*

Cap/Doc > Doc

14.5 vs 11.5

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