Ihc

P-CAD - : BRCA1: 15/19; BRCA2: 14/15; non-BRCAl/2: 29/29

Radice et al., 2003 (99)

IHC, Western Blot

Transgenic mice with human (h)P-CAD expression constrained to mammary gland epithelium: viable, no difference compared to normal phenotype, no spontaneous tumour growth. MMTV/rcet/ induced tumours: loose hP-CAD expression

Paredes et al. ,2004 (100)

Western Blot,

Functional

Assays

Breast cancer cell lines: Anti-estrogen ICI 182,780: P-CAD f in ERa positive cells, reduces cell-cell adhesion and increases invasion in MCF-7/AZ cells.

De novo P-CAD-expression (MCF-7/AZ): increases invasion but no difference in cell-cell adhesion, (HEK cells): increased invasion mediated via juxtamembranous domain

Ames et al., 2005 (101)

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