Typical Medullar breast cancer : ~ P-CAD positivity (RR=2.29)

Western Blot, RT-PCR

Invasive breast carcinoma (N=150): P-CAD expression ~ high histological grade, increased proliferation, c-erb2 and p53 expression, ER negativity and poor patient survival.

Gene promoter methylation treatment -> increased P-CAD mRNA and protein levels (MCF-7/AZ cells). Invasive carcinoma: P-CAD negativity ~ CDH3 promoter methylation (71%) and P-CAD positivity ~ unmethylated CDH3 promoter (65%)

Normal P-CAD negative breast epithelial cells: 100% CDH3 promoter methylation

Table 2. Ligand/receptor interactions regulating breast cancer cell motility and metastasis




Effect on motility and metastasis


Autocrine Motility Factor (AMF)

AMF receptor

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment