Gurpreet Singh-Ranger and Kefah Mokbel
Department of Breast and Endocrine Surgery, St. George's Hospital, London, SW17 0QT, UK
Abstract: Recent research suggests that the cyclooxygenase-2 (COX-2), an isoenzyme of the COX enzyme system has a fundamental role in breast cancer pathogenesis and metastasis. COX-2 appears to be expressed by a large proportion of invasive breast cancers and by DCIS, and levels seem to correlate with those of angiogenic factors such as VEGF, and with tumour-promoting systems such as aromatase. This is particularly important when we consider that COX-2 is amenable to suppression by simple medications such as aspirin and selective COX-2 inhibitors. This chapter reviews the research exploring the role of COX-2 in breast cancer, and studies investigating COX-2 inhibition.
Keywords: cyclooxygenase-2, breast cancer, ductal carcinoma in situ, prostaglandins, non-steroidal anti-inflammatory drugs (NSAIDs)
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