Cyclooxygenase2 And Breast Cancer

Chemo Secrets From a Breast Cancer Survivor

Breast Cancer Survivors

Get Instant Access

Gurpreet Singh-Ranger and Kefah Mokbel

Department of Breast and Endocrine Surgery, St. George's Hospital, London, SW17 0QT, UK

Abstract: Recent research suggests that the cyclooxygenase-2 (COX-2), an isoenzyme of the COX enzyme system has a fundamental role in breast cancer pathogenesis and metastasis. COX-2 appears to be expressed by a large proportion of invasive breast cancers and by DCIS, and levels seem to correlate with those of angiogenic factors such as VEGF, and with tumour-promoting systems such as aromatase. This is particularly important when we consider that COX-2 is amenable to suppression by simple medications such as aspirin and selective COX-2 inhibitors. This chapter reviews the research exploring the role of COX-2 in breast cancer, and studies investigating COX-2 inhibition.

Keywords: cyclooxygenase-2, breast cancer, ductal carcinoma in situ, prostaglandins, non-steroidal anti-inflammatory drugs (NSAIDs)

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment