Conclusions

Metastasis, the spread of cancer cells from the primary tumor to distant organs and their treatment-resistant proliferation in multiple locations, remains a major clinical and biological challenge.

The genetics of breast cancer metastasis is a very broad and complex field of study. It is relatively new and expanding. There are several potential candidates identified; however, functional validation, patient studies for relevance, and their mechanisms of action need to be elucidated. Interestingly there is not a unique signaling pathway that has emerged as a key. This further emphasizes the need for more exhaustive studies. A better understanding of the molecular mechanisms that regulate the process of metastasis and of the complex interactions between the metastatic cells and host factors can provide a biological foundation for the design of more effective therapy.

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