TJs have been increasingly shown to be deregulated in cancer cells, as a consequence of epigenetic changes, downregulation at mRNA or protein level, aberrant expression (truncated), and the activity of regulatory hormones. Many of these processes begin early in cancer progression and as such are interesting targets for diagnosis, prognosis, and treatment of breast cancer.

Studies have demonstrated a correlation between the reduction of TJs and tumour differentiation, where lower levels of TJs correlated with poorer differentiation of tumours (3). It is evident that increasing data show that TJs have a vital role to play in the prevention of cancer metastasis. TJs have emerged as the frontline structure that cancer cells must overcome in order to metastasize.

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