Cell Motility And Breast Cancer Metastasis

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Marc E. Bracke1, Daan De Maeseneer1, Veerle Van Marck1, Lara Derycke1, Barbara Vanhoecke1, Olivier De Wever1, and Herman T. Depypere2

1Laboratory of Experimental Cancer Research, Department of Experimental Cancer Research, Radiotherapy and Nuclear Medicine, 2Department of Gynaecological Oncology, University Hospital, De Pintelaan 185, B-9000 Gent, Belgium

Abstract: Motility and invasion of breast cancer cells are the result of the concerted action of a number of cell activities: directional migration underpinned by the dynamic organisation of cytoskeletal components (actin microfilaments and microtubules), establishment and disruption of cell-matrix and homotypic/heterotypic cell-cell adhesions, and extracellular proteolysis. Metastasis formation is not only related to cancer cell motility, but also necessitates the collaboration of other, coined "host" cells. Newly discovered ligand-receptor interactions between cancer cells and these host elements offer a molecular explanation for Paget's "seed and soil" hypothesis, and indicate new targets for possible anti-metastatic therapeutic agents

Keywords: motility, metastasis, breast cancer, actin, microtubles, cytoskeleton, extra-ellular matrix, collagen, laminin, hyaluronate, cadherin, CXCL12/CXCR4 interaction, integrin, CD44, proteinases

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