What is trophoblast

Within a few days following conception a ball of cells is formed called the blastocyst and the outer layer of this ball differentiates into trophoblast. This consists of an inner layer of cytotrophoblast cells that migrate outwards and fuse to form large multinucleate syn-cytiotrophoblast cells. The latter produce the pregnancy-associated hormone, human chorionic gonadotrophin (HCG), and invade the myometrium, triggering the formation of new maternal blood vessels which are leaky and supply nutrition to the growing foetus. Trophoblast tissue frequently invades these blood vessels, both in normal and molar pregnancies, and circulates in the blood.

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