Tumour suppressor genes

Examination of familial cancer syndromes (e.g. retinoblastoma) and experimental evidence (particularly from somatic cell hybrid experiments) has demonstrated the existence of a different class of cancer gene—tumour suppressor genes. p53 is the most frequently-altered gene in human tumours. Approximately 37% of all cancers have a p53 mutation (incidence is much higher with cancers of the lung and colon). Certain specific tumour mutations are associated with particular carcinogens e.g. hepatocellular carcinoma is linked with hepatitis B and aflatoxins correlates with a high incidence of mutations in codon 249 of p53.

Products of tumour suppressor genes have a variety of functions within the cell. A large number of genes have now been isolated, as can be seen in the table.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment