The optimum regimen

The clinical circumstances dominate the choice of regimen. In palliation, the fewer the attendances, the shorter the course, the sooner a response is achieved, the greater is the benefit for the patient. Regimens used for palliation generally carry a low risk of morbidity and long-term effects are usually irrelevant. Where the highest doses must be given to achieve tumour cure, as when radiotherapy alone is employed with the intention of cure, a low dose per fraction—not exceeding 2 Gy—should be employed in order to minimize the risk of late radiation damage.

A clinical oncologist should employ a wide range of schedules to best deal with all the situations where radiotherapy may benefit the cancer patient.

f CHART Continuous Hyperfractionated Accelerated Radiotherapy Trial

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