Terminology

Pharmacokinetics is the study of processes that a drug undergoes between time of administration and time of elimination from the body. The most common pharmacokinetic data is a plot of plasma drug concentration versus time. The administered dose and parameters corresponding to rate and extent of the pharmacokinetic processes determine peak drug concentration, half-life, and drug exposure (the area under the plasma concentration versus time curve or AUC). These processes are:

♦ Bioavailability, for drug absorption

♦ Clearance, for elimination

♦ Apparent volume of distribution, for distribution Pharmacodynamics describe the relation of both the therapeutic and toxic effects of a drug to the pharmacokinetic parameters.

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