Targeting agents

Tumour targeting depends on the existence of biological differences between normal and tumour cells. Several categories of targeting agent have been used, or are under development:

♦ Monoclonal antibodies—limited discriminatory ability

—epitopes are heterogenous and unstable in tumour cell population —poor penetration of tumour mass —murine antibodies provoke host response —used in cancer of ovary, colon, brain with modest response —best response in B-cell lymphoma

♦ MIBG—taken up by catecholamine-synthesizing cells of sympa thetic nervous system —taken up by neuroblastoma, phaeochromocytoma —diagnostic and therapeutic

—glioma, squamous cell carcinoma: overexpressed cell receptor epidermal growth factor (EGF)

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