Sideeffects of cisplatin

♦ Dose-dependant nephrotoxicity —prehydrate

—may need diuretics

♦ Nausea, vomiting

—all require anti-emetics

♦ Peripheral neuropathy —sensory loss —segmental demyelination

♦ Central nervous toxicity —less common

♦ Leucopenia

—recovers in 21 days

♦ Thrombocytopenia —recovers in 21 days

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