♦ Higher concentration of targeting agent
♦ Higher radiation dose to tumour deposit
♦ Cancer of the ovary—intraperitoneal 131I or 90Y conjugated antibodies
♦ Cancer of the bladder—intravesical radio-labelled antibody
♦ Brain tumours—intrathecal or intraventricular administration; CSF
♦ Injection of radiolabelled agent directly into macroscopic tumour e.g. cystic glioma
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