Regional treatment

♦ Higher concentration of targeting agent

♦ Higher radiation dose to tumour deposit

♦ Cancer of the ovary—intraperitoneal 131I or 90Y conjugated antibodies

♦ Cancer of the bladder—intravesical radio-labelled antibody

♦ Brain tumours—intrathecal or intraventricular administration; CSF

♦ Injection of radiolabelled agent directly into macroscopic tumour e.g. cystic glioma

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