Pathology

♦ Ovum lacking maternal nucleus DNA fertilized by one or two sperm—duplicate its chromosomes

♦ Conceptus is androgenetic

♦ Proliferate to give abnormal trophoblastic tissue

♦ Partial mole—arises when two sperm fertilize an ovum that has retained nuclear DNA

—triploid conceptus proliferation, to give abnormal trophoblast and variable foetal tissue —abnormal trophoblast forms hydropic villi which resemble grapes

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