Tumours can derive from all cell types of origin in the small intestine. The same staging system as for colorectal tumours is usually used.

In general, initial symptoms of small bowel tumours are rather vague and a diagnostic delay of 8-12 months is common. Tumour markers are useful for carcinoids, particularly chromogranin A and 5-HIAA. Markers such as CEA, CA-19-9, CA-50 are too non-specific for diagnosing small bowel tumours. Any patient who has a primary small bowel malignancy should be monitored for the development of a second malignant tumour, frequently in the colon.

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