Pathology

Two broad groups of tumours may be recognized by their histological appearances:

Favourable histology—by far the larger group

♦ Classical triphasic histology—epithelial, blastemal, and stromal elements are all present.

♦ Rhabdomyoblastic differentiation, such that the cells resemble fetal rhabdomyoblasts.

♦ Monomorphic epithelial variant.

Unfavourable histology

♦ Anaplasia is an unfavourable, often patchy occasionally observed in triphasic tumours. The major unfavourable histological types are probably distinct tumours, rather than true variants of Wilms' tumour.

♦ Bone-metastasizing renal tumour of childhood.

♦ Malignant rhabdoid tumour.

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