Two broad groups of tumours may be recognized by their histological appearances:
Favourable histology—by far the larger group
♦ Classical triphasic histology—epithelial, blastemal, and stromal elements are all present.
♦ Rhabdomyoblastic differentiation, such that the cells resemble fetal rhabdomyoblasts.
♦ Monomorphic epithelial variant.
♦ Anaplasia is an unfavourable, often patchy occasionally observed in triphasic tumours. The major unfavourable histological types are probably distinct tumours, rather than true variants of Wilms' tumour.
♦ Bone-metastasizing renal tumour of childhood.
♦ Malignant rhabdoid tumour.
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