Pancytopenia in the cancer patient

♦ Neutropenia—life-threatening bacterial infections

♦ Associated with—poor nutrition

—mucosal barrier defects —abnormal host colonization

♦ Qualitative and quantitative defects

♦ Defects in chemotaxis, neutrophil degranulation

Table 33.2 Most common micro-organisms in neutropenic patients

Gram-negative bacilli

Gram-positive bacilli

Fungi

E. coli

Staphylococcus aureus

Candida spp

Klebsiella spp

Staphylococcus epidermidis

Aspergillus spp

Enterobacter spp

Streptococcus pneumoniae

Mucorales

Proteus spp

Viridans streptococci

P. aeroginosa

Enterococci Corynebacterium

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