Oxaliplatin

Oxaliplatin is a platinum analogue that differs from carboplatin and cisplatin, in both chemical behaviour and possibly its mechanism of action. Availability is limited. In vitro oxaliplatin has a broad spectrum of activity with marked differences from the spectrum seen with cisplatin or carboplatin e.g. oxaliplatin appears to be active in those cell lines that are resistant to cisplatin, and a high level of activity is seen in colorectal cell lines. This has led to multiple Phase I, II, and III studies of the agent, evaluating its activity in colorectal cancer.

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