New approaches

The overall response rate to platinum-paclitaxel therapy is 70-75% with 30-50% of patients achieving a complete clinical remission. The question has been raised whether some form of consolidation or maintenance therapy should be investigated. Possible approaches include:

♦ Intra-peritoneal chemotherapy

♦ High-dose systemic chemotherapy

♦ Biological response modifiers

♦ Metalloprotinease inhibitors

♦ Anti-angiogenic agents

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