Multidrug resistance protein MRP

This protein is one member of a family of proteins which also act as energy-dependent pumps, in this case resulting in drug efflux or sequestration of the drug, within intracytoplasmic organelles or vacuoles. The most studied member of this family of proteins is 190 kilodalton protein which has a similar substrate specificity to p-glycoprotein but is usually associated with less resistance to the taxanes. The clinical relevance of this form of resistance is less clear than with the p-glycoprotein; clinical trials looking at inhibition of MRP are at an early stage.

0 0

Post a comment