Monoclonal antibodies

The development of monoclonal antibodies that recognize human tumour-associated antigens has implications for nuclear medicine. Antibodies and fragments (Fab) can be labelled with 131I, 123I, mIn, and 99mTc for scintigraphy. In colorectal cancer, scintigraphy with monoclonal antibodies is potentially valuable in detecting occult disease, localizing recurrent disease when serum markers are elevated, and differentiating between viable tumour and post-surgical fibrosis. The potential roles for radio-immunoscintigraphy in ovarian cancer are in the evaluation of chemotherapy, of pelvic masses after therapy for the presence of viable tumour, and of raised serum markers.

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