Mitoxantrone

One of the anthracenediones, synthesized as analogue of the anthra-cyclines. In common with the anthracyclines, mitoxantrone binds to DNA and interacts with topoisomerase II but appears less potent in generating free radicals. Mitoxantrone is also a substrate for Pgp.

Like doxorubicin, mitoxantrone is rapidly and highly tissue-bound. The main clinical use of mitoxantrone has been as an alternative to doxorubicin in advanced breast cancer, as it is substantially less cardiotoxic, less vesicant, and causes less alopecia. However, mitox-antrone is less effective than doxorubicin. It has some activity against other solid tumours, including non-Hodgkin's lymphoma and non-lymphocytic leukaemia.

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