Mitoxantrone

One of the anthracenediones, synthesized as analogue of the anthra-cyclines. In common with the anthracyclines, mitoxantrone binds to DNA and interacts with topoisomerase II but appears less potent in generating free radicals. Mitoxantrone is also a substrate for Pgp.

Like doxorubicin, mitoxantrone is rapidly and highly tissue-bound. The main clinical use of mitoxantrone has been as an alternative to doxorubicin in advanced breast cancer, as it is substantially less cardiotoxic, less vesicant, and causes less alopecia. However, mitox-antrone is less effective than doxorubicin. It has some activity against other solid tumours, including non-Hodgkin's lymphoma and non-lymphocytic leukaemia.

Hair Loss Prevention

Hair Loss Prevention

The best start to preventing hair loss is understanding the basics of hair what it is, how it grows, what system malfunctions can cause it to stop growing. And this ebook will cover the bases for you. Note that the contents here are not presented from a medical practitioner, and that any and all dietary and medical planning should be made under the guidance of your own medical and health practitioners. This content only presents overviews of hair loss prevention research for educational purposes and does not replace medical advice from a professional physician.

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