Left ventricular function in cardiac injury

Doxorubicin and other anthracycline derivatives are effective chemotherapeutic agents, but one of the major limiting side-effects is cardiotoxicity. An essential aspect in the treatment strategy is serial monitoring of left ventricular ejection fraction (LVEF) at rest. Radionuclide ventriculography can be performed under standardized conditions, ensuring a good reproducibility that is essential in serial measurements. A decline in LVEF is a relatively late symptom of cardiotoxicity. Recently, methods to detect directly the myocyte damage by mIn-labeUed antimyosin scintigraphy have been developed.

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