Invasion methodology

Tumour invasion and metastases is a complex, dynamic, multi-step process:

♦ Initial invasion of tumour through basement membrane.

♦ Movement into connective tissue surrounding tumour cells.

♦ Invasion of tumour cells into blood vessels.

♦ Circulating tumour cells are arrested in blood vessels of a distant organ or tissue; tumour cells invade organ from blood vessels.

♦ Tumour cells then grow within tissue to form a metastatic tumour that may become clinically evident.

♦ Process of tumour invasion and metastases results from alterations in cell-to-cell and cell-to-matrix adhesion and increased matrix degradation.

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